EWAS Atlas: a curated knowledgebase of epigenome-wide association studies
نویسندگان
چکیده
منابع مشابه
Epigenome-Wide Association Studies (EWAS) in Cancer
After completion of the human genome, genome-wide association studies were conducted to identify single nucleotide polymorphisms (SNPs) associated with cancer initiation and progression. Most of the studies identified SNPs that were located outside the coding region, and the odds ratios were too low to implement in clinical practice. Although the genome gives information about genome sequence a...
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Similar to the SNP (single nucleotide polymorphism) data, there is non-random association of the DNA methylation level (we call it methylation disequilibrium, MD) between neighboring methylation loci. For the case-control study of complex diseases, it is important to identify the association between methylation levels combination types (we call it methylecomtype) and diseases/phenotypes. We ext...
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Epigenome-wide association studies (EWAS) are designed to characterise population-level epigenetic differences across the genome and link them to disease. Most commonly, they assess DNA-methylation status at cytosine-guanine dinucleotide (CpG) sites, using platforms such as the Illumina 450k array that profile a subset of CpGs genome wide. An important challenge in the context of EWAS is determ...
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Epigenome-wide association studies represent one means of applying genome-wide assays to identify molecular events that could be associated with human phenotypes. The epigenome is especially intriguing as a target for study, as epigenetic regulatory processes are, by definition, heritable from parent to daughter cells and are found to have transcriptional regulatory properties. As such, the epi...
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☆ WorkshopparticipantDr. Arturas Petronis from the Cen Health at the University of Toronto, Canada, preferred not ⁎ Corresponding author. Tel.: +1 17186781234; fax: + E-mail address: [email protected] (J.M. Gre http://dx.doi.org/10.1016/j.nepig.2014.10.004 2214-7845/© 2014 The Authors. Published by Elsevier Inc Article history: Received 13 October 2014 Accepted 14 October 2014
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2018
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gky1027